Coach Dies in Freak Accident, California High School in Mourning

Marion Adams - a multimedia teacher and track and field coach at Rio Londa High School in California - died this week in a terrifying bicycle accident, reports The Sacramento Bee.

The 59-year old was riding away from practice on Monday when he looked over his shoulder to bid farewell to a student.

Tragically, Adams therefore failed to see a partially opened metal gate in the school parking lot and could not slow down in time to avoid it.

He was impaled on the structure, rushed to Mercy San Juan Hospital and initially survived two surgeries to treat internal injuries before passing away.

"Marion was the most popular and nicest man on campus; just a great guy," Athletic Director Mike Morris told the newspaper. "It's a huge loss, devastating to our community.?

Hundreds attended a vigil held for Adams on Tuesday night.

Adams, who coached at his alma mater, is survived by wife Kathy, son Joe and daughter Sarah and two grandchildren.

Source: http://www.thehollywoodgossip.com/2013/03/coach-dies-in-freak-accident-california-high-school-in-mourning/

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Libyan army restores order at gas complex, flows suspended

MILAN/TRIPOLI (Reuters) - Libya said on Monday the army had restored order at an energy complex near Tripoli after weekend clashes between militia guards, but that gas exports to Italy would remain suspended and oil production cut back for several days.

Libyan officials said the national army and militias aligned with it had arrived at the Mellitah oil and gas complex, some 100 km (60 miles) west of Tripoli, on Sunday night. The locally deployed militias had ceased fighting but gas exports had been suspended on Monday for a third day.

"We have full control, it is safe, it is just a matter of assessing the situation to identify the one entity that will take charge of the security," said Abdulfattah Shagan, chairman of the Mellitah oil and gas venture between Libya's National Oil Corporation and Italy's Eni.

"I think the army will be in charge," he said adding that the fighting has done only minor damage to facilities.

Armed clashes erupted on Saturday after an argument between former rebel fighters from nearby Zuwara and others from Zintan over who should guard Mellitah, security officials said. Deputy Oil Minister Omar Shakmak said one person was killed and several injured.

The disruption at the Mellitah complex is the latest to hit the energy sector in Libya, where protests have shut down oil-export terminals in recent months, and comes after January's hostage-taking at an Algerian gas plant.

Thousands of former rebels who fought to overthrow former leader Muammar Gaddafi in 2011 have been employed in a protection force to look after Libyan oil and gas installations. Rivalries between militia and clan groups have posed a broader problem for Tripoli as it struggles to assert central control.

In recent months, activists and local militia have disrupted operations in Libya's main industry, pursuing goals such as better living conditions or more regional autonomy.

This has hurt OPEC member Libya's oil output, which had returned to pre-war levels of 1.6 million barrels per day (bpd) relatively fast after the 2011 revolution, but has been hit by disruptions since then.

RESTART DUE IN DAYS

Mellitah supplies Italy with gas through the Greenstream pipeline, which ends at the Sicilian port town of Gela and at full capacity pumps at least 8 billion cubic meters a year.

Shagan told Reuters that in addition to a full suspension of gas production at the Mellitah complex, the venture had to reduce oil output at its Elephant and Wafa fields by 25 percent.

That could rise to 50 percent from regular output of 210,000 barrels per day, he added.

"Once we establish full security, then we will start bringing back our staff and preparing to start up. It will take three to four days altogether," he added.

A spokesman for ENI said the plant had restarted on Monday to process small gas flows. A source close to the matter said it would take several days to ramp up processing.

Italy gets most of its gas from Algeria, Russia, and Libya - which provides between 10 and 15 percent - while some comes from Norway and the Netherlands.

Italy will compensate for the Libyan gas stoppage by raising imports from the Russian and Dutch pipelines, analysts said.

The halt in Libyan supply coincided with large scale gas supply falls due to unexpected pipeline outages in the North Sea, which at one point on Monday propelled British spot gas prices to five-year highs.

Unlike Britain, where most of the gas sold is on the spot market, Italy gets most of its gas through long-term contracts linked to the oil price.

Italy saw its gas imports from Libya suspended for several months during the 2011 civil war that ultimately led to the fall of former leader Muammar Gaddafi.

(Reporting by Marie-Louise Gumuchian, Ali Shuaib, Stephen Jewkes and Giancarlo Navach; Editing by Anthony Barker and Robin Pomeroy)

Source: http://news.yahoo.com/libyan-army-restores-order-gas-complex-flows-suspended-182611693--finance.html

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Misplaced molecules: New insights into the causes of dementia

Monday, March 4, 2013

A shortage of a protein called TDP-43 caused muscle wasting and stunted nerve cells. This finding supports the idea that malfunction of this protein plays a decisive role in ALS and FTD. The study is published in the "Proceedings of the National Academy of Sciences of the USA" (PNAS).

ALS is an incurable neurological disease which manifests as rapidly progressing muscle wasting. Both limbs and respiratory muscles are affected. This leads to impaired mobility and breathing problems. Patients commonly die within a few years after the symptoms emerged. In rare cases, of which the British physicist Stephen Hawking is the most notable, patients can live with the disease for a long time. In Germany estimates show over 150,000 patients suffering from ALS ? an average of 1 in 500 people.

Proteins gone astray

Over the last few years, there has been increasing evidence that ALS and FTD ? a form of dementia associated with changes in personality and social behaviour ? may have similar or even the same origins. The symptoms overlap and common factors have also been found at the microscopic level. In many cases, particles accumulate and form clumps in the patient's nerve cells: this applies particularly to the TDP-43 protein.

"Normally, this protein is located in the cell nucleus and is involved in processing genetic information," explains molecular biologist Dr. Bettina Schmid, who works at the DZNE Munich site and at LMU. "However, in cases of disease, TDP-43 accumulates outside the nucleus forming aggregates." Schmid explains that it is not yet clear whether these clumps are harmful. "However, the protein's normal function is clearly disrupted. It no longer reaches the nucleus to perform its actual task. There seems to be a relationship between this malfunction and the disease."

Studies on zebrafish

However, until now little was known about the function of TDP-43. What are the consequences when this protein becomes non-functional? In order to answer this question, the team led by Bettina Schmid cooperated with the research group of Prof. Christian Haass to investigate the larvae of specially bred zebrafish. Their genetic code had been modified in such a way that no TDP-43 was produced in the organism of the fish. The result: the young fish showed massive muscle wasting and died a few days after hatching. Moreover, the extensions of the nerve cells which control the muscles were abnormal.

"To some extent, these are symptoms typical of ALS and FTD. Therefore, a loss of function of TDP-43 does seem to play a critical role in the disease," says Haass, Site Speaker of the DZNE Munich Site and chair of Metabolic Biochemistry at LMU.

The study revealed one more finding which surprised the researchers: the blood flow of the fish was massively disturbed. "It is well known that circulatory disorders play a part in other forms of dementia, notably in the case of Alzheimer's," says Haass. "We now want to investigate whether such problems with blood flow may be a general problem of neurodegenerative diseases and whether such problems occur particularly in patients with ALS and FTD."

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Helmholtz Association of German Research Centres: http://www.helmholtz.de/en/index.html

Thanks to Helmholtz Association of German Research Centres for this article.

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Source: http://www.labspaces.net/127105/Misplaced_molecules__New_insights_into_the_causes_of_dementia

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